ABSTRACT
Pandemic of COVID-19 has brought significant changes not only to the daily life of mankind, but also to the course of many chronic diseases. In addition to lung damage, extrapulmonary manifestations may develop against the background of coronavirus disease progression. These changes often have multi-organ nature, espe cially against the background of existing chronic diseases. Literature describes cardiac, neurologic, renal extrapulmonary SARS-CoV-2 lesions as well as eye damage. Gastrointestinal tract is one of the areas affected by SARS-CoV-2 virus. This impact is stipulated by the significant effects of virus on the microbiota and permeability of mucosal barriers, as well as important role of changes in the intestinal barrier function in the development of local and systemic immune response. Working group of the Ukrainian Gastroenterological Association (UGA) worked out a classification of intestinal post-covid lesions, which was presented at the UGA congress in September 2021. The following types of damage have been outlined: COVID-19 induced bacterial overgrowth syndrome, functional diarrhea after previous COVID-19 infection, infection-induced irritable bowel syndrome (post-infectious IBS), antibiotic-associated diarrhea (without Clostridium difficile and pseudomembranous colitis with confirmed Clostridium difficile), exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn's disease), newly diagnosed (COVID-induced) inflammatory bowel disease. The course of functional and inflammatory diseases can be modified by COVID-19, affecting the gut microbiome. It is necessary to conduct a thorough differential diagnosis of exacerbation of functional, inflammatory and post-covid lesions of the intestine. Complex therapy including agents to correct dysbiosis should be used to treat this group of patients. © Modern gastroenterology, 2022.